/* ============================================================
   TheraTrials Oncology — Páginas profundas por radiofármaco
   Estilo compartilhado entre Lu-PSMA, Lu-DOTATATE, Ra-223,
   Y-90, MIBG, Novos Alfa-emissores
   ============================================================ */

.rf-hero {
  padding: 4rem 0 3rem;
  position: relative;
  overflow: hidden;
}
.rf-hero::before {
  content: '';
  position: absolute;
  top: 50%; left: 50%;
  width: 700px; height: 700px;
  transform: translate(-50%, -50%);
  background: radial-gradient(circle, rgba(255, 132, 0, 0.08) 0%, transparent 60%);
  pointer-events: none;
  z-index: 0;
}
.rf-hero .container { position: relative; z-index: 1; }

.rf-eyebrow {
  display: inline-flex; align-items: center; gap: 0.5rem;
  padding: 0.4rem 0.85rem;
  background: var(--amber-soft);
  border: 1px solid rgba(255, 132, 0, 0.25);
  border-radius: 100px;
  color: var(--amber);
  font-size: 0.78rem; font-weight: 500;
  text-transform: uppercase; letter-spacing: 0.08em;
  margin-bottom: 1.25rem;
}

.rf-title {
  font-family: var(--font-display);
  font-size: clamp(2.2rem, 4.5vw, 3.6rem);
  font-weight: 700;
  letter-spacing: -0.025em;
  line-height: 1.05;
  margin: 0 0 1rem;
}
.rf-title .accent { color: var(--amber); }
.rf-title .iso-up { font-size: 0.55em; vertical-align: 0.7em; color: var(--amber); font-weight: 600; }

.rf-subtitle {
  color: var(--stone);
  font-size: 1.1rem;
  max-width: 700px;
  margin-bottom: 2rem;
}

/* ID card do isótopo */
.iso-card {
  display: grid;
  grid-template-columns: auto 1fr;
  gap: 2rem;
  align-items: center;
  background: linear-gradient(135deg, rgba(255, 132, 0, 0.06) 0%, rgba(14, 165, 183, 0.04) 100%);
  border: 1px solid var(--border-soft);
  border-radius: var(--radius-lg);
  padding: 1.75rem;
  margin-top: 1.5rem;
}
@media (max-width: 720px) { .iso-card { grid-template-columns: 1fr; } }

.iso-symbol {
  width: 140px; height: 140px;
  border-radius: 50%;
  background: radial-gradient(circle at 35% 35%, var(--amber-glow) 0%, var(--amber) 55%, #B85D00 100%);
  display: flex; flex-direction: column;
  align-items: center; justify-content: center;
  color: #0E0F12; font-family: var(--font-display);
  box-shadow: 0 0 50px rgba(255, 132, 0, 0.35);
  flex-shrink: 0;
  position: relative;
}
.iso-symbol.alpha {
  background: radial-gradient(circle at 35% 35%, #D9A6FF 0%, #C084FC 55%, #7E3FB8 100%);
  box-shadow: 0 0 50px rgba(192, 132, 252, 0.35);
}
.iso-symbol.alpha::before { border-color: rgba(192, 132, 252, 0.4) !important; }
.iso-symbol::before {
  content: '';
  position: absolute;
  top: -8px; right: -8px; bottom: -8px; left: -8px;
  border: 1px dashed rgba(255, 132, 0, 0.4);
  border-radius: 50%;
  animation: rotate 24s linear infinite;
}
@keyframes rotate { to { transform: rotate(360deg); } }
.iso-mass { font-size: 0.85rem; font-weight: 600; opacity: 0.7; line-height: 1; }
.iso-element { font-size: 2.6rem; font-weight: 700; line-height: 1; }
.iso-name { font-size: 0.7rem; opacity: 0.7; margin-top: 0.15rem; }

.iso-grid {
  display: grid; grid-template-columns: repeat(auto-fit, minmax(120px, 1fr));
  gap: 1rem;
}
.iso-grid .item { }
.iso-grid .lbl { font-size: 0.7rem; color: var(--stone); text-transform: uppercase; letter-spacing: 0.08em; }
.iso-grid .val { font-family: var(--font-mono); font-size: 1.05rem; color: var(--off-white); margin-top: 0.2rem; font-weight: 500; }

/* Sumário lateral */
.toc {
  position: sticky; top: 90px;
  background: var(--graphite-2);
  border: 1px solid var(--border-soft);
  border-radius: var(--radius-md);
  padding: 1.25rem;
}
.toc h4 { font-size: 0.78rem; text-transform: uppercase; letter-spacing: 0.1em; color: var(--stone); margin: 0 0 0.85rem; font-weight: 600; }
.toc a {
  display: block;
  color: var(--off-white); opacity: 0.7;
  font-size: 0.9rem; padding: 0.4rem 0.5rem;
  border-radius: var(--radius-sm); margin-bottom: 0.15rem;
  transition: all 0.15s;
  border-left: 2px solid transparent;
}
.toc a:hover { opacity: 1; background: var(--graphite-3); border-left-color: var(--amber); }

.rf-layout {
  display: grid;
  grid-template-columns: 220px 1fr;
  gap: 3rem;
  padding: 2rem 0;
}
@media (max-width: 968px) {
  .rf-layout { grid-template-columns: 1fr; }
  .toc { position: static; }
}

/* Sections */
.rf-section { margin-bottom: 3.5rem; scroll-margin-top: 90px; }
.rf-section h2 {
  font-family: var(--font-display);
  font-size: 1.85rem; font-weight: 600;
  letter-spacing: -0.015em;
  margin: 0 0 0.5rem;
  display: flex; align-items: center; gap: 0.85rem;
}
.rf-section h2 .num {
  font-size: 0.9rem;
  font-family: var(--font-mono);
  color: var(--amber);
  background: var(--amber-soft);
  padding: 0.2rem 0.6rem;
  border-radius: 6px;
  border: 1px solid rgba(255, 132, 0, 0.25);
  font-weight: 500;
}
.rf-section .lead { color: var(--stone); font-size: 1rem; margin-bottom: 1.75rem; max-width: 720px; }

/* Cronologia */
.timeline {
  position: relative;
  padding: 1rem 0 1rem 0;
  margin-top: 1rem;
}
.timeline::before {
  content: '';
  position: absolute;
  left: 26px; top: 0; bottom: 0;
  width: 2px;
  background: linear-gradient(to bottom, transparent 0%, var(--amber) 8%, var(--teal) 92%, transparent 100%);
}
.tl-item {
  display: grid;
  grid-template-columns: 70px 1fr;
  gap: 1.25rem;
  margin-bottom: 1.5rem;
  align-items: flex-start;
}
.tl-dot {
  width: 52px; height: 52px;
  border-radius: 50%;
  background: #0E0F12;
  border: 2px solid var(--amber);
  display: flex; align-items: center; justify-content: center;
  color: var(--amber); font-family: var(--font-display);
  font-size: 0.92rem; font-weight: 600; letter-spacing: -0.01em;
  box-shadow: 0 0 16px rgba(255, 132, 0, 0.3);
  flex-shrink: 0;
  position: relative;
  z-index: 1;
}
.tl-dot.period {
  font-size: 0.72rem;
  line-height: 1;
  flex-direction: column;
  gap: 2px;
}
.tl-dot.period span { display: block; }

.tl-card {
  background: var(--graphite-2);
  border: 1px solid var(--border-soft);
  border-radius: var(--radius-md);
  padding: 1.1rem 1.25rem;
}
.tl-card h4 { margin: 0 0 0.35rem; font-size: 1.05rem; color: var(--off-white); font-weight: 600; }
.tl-card p { margin: 0; color: var(--stone); font-size: 0.92rem; line-height: 1.55; }

/* Mecanismo - diagrama */
.mech-diagram {
  background: var(--graphite-2);
  border: 1px solid var(--border-soft);
  border-radius: var(--radius-lg);
  padding: 2rem;
  margin: 1.5rem 0;
}
.mech-stages {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
  gap: 1rem;
  margin-top: 1.5rem;
}
.mech-stage {
  background: var(--graphite-3);
  border: 1px solid var(--border-soft);
  border-radius: var(--radius-md);
  padding: 1.25rem;
  text-align: center;
  position: relative;
}
.mech-stage .mech-num {
  width: 32px; height: 32px;
  border-radius: 50%;
  background: var(--amber);
  color: #0E0F12;
  font-weight: 700;
  display: inline-flex; align-items: center; justify-content: center;
  margin-bottom: 0.75rem;
}
.mech-stage h5 { margin: 0 0 0.4rem; font-size: 0.95rem; color: var(--off-white); font-weight: 600; }
.mech-stage p { margin: 0; font-size: 0.82rem; color: var(--stone); line-height: 1.5; }

/* Esquema terapêutico */
.scheme-box {
  background: linear-gradient(135deg, rgba(255, 132, 0, 0.07) 0%, rgba(14, 165, 183, 0.05) 100%);
  border: 1px solid rgba(255, 132, 0, 0.25);
  border-radius: var(--radius-lg);
  padding: 2rem;
  margin: 1.5rem 0;
}
.scheme-pills {
  display: flex; flex-wrap: wrap; gap: 0.75rem;
  margin: 1rem 0 1.5rem;
}
.scheme-pill {
  display: inline-flex; align-items: center; gap: 0.5rem;
  background: var(--graphite-2);
  border: 1px solid var(--border-soft);
  padding: 0.6rem 1rem;
  border-radius: 100px;
  font-family: var(--font-mono);
  font-size: 0.88rem;
}
.scheme-pill .pill-lbl { color: var(--stone); font-size: 0.7rem; text-transform: uppercase; letter-spacing: 0.06em; }
.scheme-pill .pill-val { color: var(--amber); font-weight: 600; }

/* Cycle bar */
.cycle-bar {
  display: grid;
  grid-template-columns: repeat(6, 1fr);
  gap: 0.5rem;
  margin-top: 1.5rem;
}
.cycle {
  background: var(--graphite-3);
  border: 1px solid rgba(255, 132, 0, 0.3);
  border-radius: var(--radius-sm);
  padding: 0.85rem 0.5rem;
  text-align: center;
}
.cycle .cy-num { color: var(--amber); font-weight: 700; font-family: var(--font-mono); font-size: 1rem; }
.cycle .cy-week { color: var(--stone); font-size: 0.72rem; text-transform: uppercase; letter-spacing: 0.05em; margin-top: 0.25rem; }
.cycle .cy-dose { font-family: var(--font-mono); font-size: 0.78rem; color: var(--off-white); margin-top: 0.4rem; }

/* Ensaios pivotais */
.trials-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));
  gap: 1.25rem;
  margin-top: 1.5rem;
}
.trial-card {
  background: var(--graphite-2);
  border: 1px solid var(--border-soft);
  border-radius: var(--radius-md);
  padding: 1.5rem;
  transition: all 0.2s;
}
.trial-card:hover { border-color: rgba(255, 132, 0, 0.4); transform: translateY(-2px); }
.trial-name {
  display: flex; align-items: baseline; gap: 0.6rem;
  margin-bottom: 0.6rem;
}
.trial-name .name { font-size: 1.15rem; font-weight: 700; color: var(--amber); font-family: var(--font-display); }
.trial-name .year { color: var(--stone); font-size: 0.85rem; font-family: var(--font-mono); }
.trial-card .pop { color: var(--stone); font-size: 0.88rem; margin: 0 0 0.85rem; }
.trial-card .results { display: grid; grid-template-columns: 1fr 1fr; gap: 0.5rem; margin-bottom: 0.75rem; }
.trial-card .stat-row { background: var(--graphite-3); padding: 0.55rem 0.75rem; border-radius: var(--radius-sm); }
.trial-card .stat-row .lbl { font-size: 0.7rem; color: var(--stone); text-transform: uppercase; letter-spacing: 0.05em; }
.trial-card .stat-row .val { font-family: var(--font-mono); font-size: 0.92rem; color: var(--off-white); margin-top: 0.15rem; font-weight: 500; }
.trial-card .takeaway {
  color: var(--off-white); font-size: 0.88rem;
  margin: 0; padding-top: 0.75rem;
  border-top: 1px solid var(--border-soft);
}

/* Critérios PSMA-PET / outras eligibilidades */
.criteria-box {
  background: var(--graphite-2);
  border: 1px solid var(--border-soft);
  border-radius: var(--radius-md);
  padding: 1.5rem;
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 2rem;
  margin: 1.5rem 0;
}
@media (max-width: 768px) { .criteria-box { grid-template-columns: 1fr; } }
.criteria-col h5 { font-size: 1rem; margin: 0 0 0.85rem; display: flex; align-items: center; gap: 0.5rem; }
.criteria-col.include h5 { color: var(--success); }
.criteria-col.exclude h5 { color: #F87171; }
.criteria-list { list-style: none; padding: 0; margin: 0; }
.criteria-list li {
  padding: 0.55rem 0 0.55rem 1.6rem;
  position: relative;
  font-size: 0.9rem; color: var(--off-white);
  border-bottom: 1px solid var(--border-soft);
}
.criteria-list li:last-child { border-bottom: 0; }
.criteria-list li::before {
  position: absolute; left: 0; top: 0.55rem;
  font-family: var(--font-mono); font-weight: 700;
}
.criteria-col.include .criteria-list li::before { content: '✓'; color: var(--success); }
.criteria-col.exclude .criteria-list li::before { content: '✕'; color: #F87171; }

/* Dosimetria */
.dose-table {
  width: 100%;
  border-collapse: collapse;
  background: var(--graphite-2);
  border: 1px solid var(--border-soft);
  border-radius: var(--radius-md);
  overflow: hidden;
  margin: 1.5rem 0;
}
.dose-table th, .dose-table td {
  padding: 0.85rem 1rem;
  text-align: left;
  border-bottom: 1px solid var(--border-soft);
  font-size: 0.92rem;
}
.dose-table th { background: var(--graphite-3); color: var(--stone); font-weight: 600; font-size: 0.78rem; text-transform: uppercase; letter-spacing: 0.05em; }
.dose-table tr:last-child td { border-bottom: 0; }
.dose-table tr:hover { background: var(--graphite-3); }
.dose-bar {
  position: relative;
  height: 8px;
  background: var(--graphite-4);
  border-radius: 4px;
  overflow: hidden;
  min-width: 100px;
}
.dose-bar-fill {
  position: absolute; left: 0; top: 0; bottom: 0;
  background: linear-gradient(90deg, var(--amber), var(--amber-glow));
  border-radius: 4px;
}
.dose-bar.high .dose-bar-fill { background: linear-gradient(90deg, #F87171, #FBA876); }
.dose-bar.med .dose-bar-fill { background: linear-gradient(90deg, var(--warn), #FCD34D); }
.dose-bar.low .dose-bar-fill { background: linear-gradient(90deg, var(--success), #6EE7B7); }

/* Toxicidade */
.tox-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(220px, 1fr));
  gap: 0.85rem;
  margin: 1.5rem 0;
}
.tox-item {
  background: var(--graphite-2);
  border: 1px solid var(--border-soft);
  border-radius: var(--radius-md);
  padding: 1rem 1.15rem;
}
.tox-item .tox-name { font-size: 0.92rem; font-weight: 500; margin-bottom: 0.5rem; }
.tox-item .tox-pct {
  display: flex; align-items: baseline; gap: 0.6rem;
  margin-bottom: 0.4rem;
}
.tox-item .tox-all { font-family: var(--font-mono); font-size: 1.4rem; font-weight: 700; color: var(--off-white); }
.tox-item .tox-g3 { font-family: var(--font-mono); font-size: 0.85rem; color: #F87171; }
.tox-item .tox-bar {
  height: 6px;
  background: var(--graphite-4);
  border-radius: 3px;
  overflow: hidden;
  position: relative;
}
.tox-item .tox-bar-all {
  position: absolute; left: 0; top: 0; bottom: 0;
  background: linear-gradient(90deg, var(--amber), var(--amber-glow));
  border-radius: 3px;
}

/* Box destaque (key fact) */
.key-fact {
  background: var(--graphite-2);
  border-left: 3px solid var(--amber);
  border-radius: 0 var(--radius-md) var(--radius-md) 0;
  padding: 1.15rem 1.5rem;
  margin: 1.5rem 0;
}
.key-fact .lbl {
  font-size: 0.7rem; color: var(--amber);
  text-transform: uppercase; letter-spacing: 0.1em;
  font-weight: 600;
  margin-bottom: 0.4rem;
}
.key-fact p { margin: 0; color: var(--off-white); font-size: 0.95rem; line-height: 1.55; }

/* Comparação alfa vs beta */
.ab-compare {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 1.25rem;
  margin: 1.5rem 0;
}
@media (max-width: 700px) { .ab-compare { grid-template-columns: 1fr; } }
.ab-card {
  background: var(--graphite-2);
  border: 1px solid var(--border-soft);
  border-radius: var(--radius-md);
  padding: 1.5rem;
}
.ab-card.beta { border-color: rgba(255, 132, 0, 0.3); }
.ab-card.alpha { border-color: rgba(192, 132, 252, 0.35); }
.ab-card h4 {
  margin: 0 0 0.85rem;
  font-size: 1.1rem;
  display: flex; align-items: center; gap: 0.6rem;
}
.ab-card.beta h4 { color: var(--amber); }
.ab-card.alpha h4 { color: #C084FC; }
.ab-card ul { margin: 0; padding: 0; list-style: none; }
.ab-card li {
  padding: 0.45rem 0;
  border-bottom: 1px solid var(--border-soft);
  font-size: 0.88rem;
  color: var(--off-white);
  display: flex; justify-content: space-between; gap: 1rem;
}
.ab-card li:last-child { border-bottom: 0; }
.ab-card li .v { font-family: var(--font-mono); color: var(--stone); }

/* Orbital divider */
.orbital-divider {
  display: flex; justify-content: center; align-items: center;
  padding: 2.5rem 0;
}

/* Link cards no fim */
.next-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(220px, 1fr));
  gap: 1rem;
  margin-top: 1.5rem;
}
.next-card {
  background: var(--graphite-2);
  border: 1px solid var(--border-soft);
  border-radius: var(--radius-md);
  padding: 1.25rem;
  transition: all 0.2s;
  text-decoration: none;
  color: var(--off-white);
  display: block;
}
.next-card:hover { border-color: rgba(255, 132, 0, 0.4); transform: translateY(-2px); color: var(--off-white); }
.next-card .lbl { font-size: 0.7rem; color: var(--amber); text-transform: uppercase; letter-spacing: 0.08em; font-weight: 600; margin-bottom: 0.3rem; }
.next-card .name { font-size: 1.05rem; font-weight: 600; margin-bottom: 0.2rem; }
.next-card .desc { font-size: 0.82rem; color: var(--stone); }

/* Cards genéricos para imagem teranóstica */
.imaging-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(220px, 1fr));
  gap: 1rem;
  margin: 1.5rem 0;
}
.imaging-card {
  background: var(--graphite-2);
  border: 1px solid var(--border-soft);
  border-radius: var(--radius-md);
  padding: 1.25rem;
}
.imaging-card .tag { font-family: var(--font-mono); color: var(--amber); font-size: 0.85rem; margin-bottom: 0.4rem; }
.imaging-card .title { font-size: 0.95rem; color: var(--off-white); margin-bottom: 0.35rem; }
.imaging-card .desc { font-size: 0.82rem; color: var(--stone); line-height: 1.5; }